Essentials of Gynecologic and Obstetric Endocrinology

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August 1975



This book concisely presents the essential information in the field of gyneco­ logic endocrinology. Textual material is extensively supplemented by schemes, tables, and diagrams to elucidate etiologies, pathophysiologic mechanisms, and natural histories of the various clinical disorders in the field. The most timely and up-to-date laboratory procedures and physiologic manipulations for diagnosis are presented. Management rationales based on the definitive diagnostic studies and on knowledge of the natural histories are also presented. Special emphasis is placed on the roles of suprahypothalamic as well as extragonadal and peripheral factors in the pathogenesis of many of the disorders of the menstrual cycle. These include the influence of diseases, altered physiologic states, and drugs-areas which are largely neglected in other presentations of this field. The material presented is based on courses in gynecologic endocrinology presented at the Lorna Linda University School of Medicine and at other institutions over the past several years. Extensive use is made of authoritative reviews in this field, and only highly controversial material is authenticated by specific references. I am deeply grateful to Mrs. Lucille Innes of the Audiovisual Department at Lorna Linda University for the artwork. The loyal secretarial help of Alice Hickman, Carol Guzman, and Robbie Cleek is gratefully acknowledged. Habeeb Bacchus, Ph.D., M.D., F.A.C.P.


1. Mechanisms of Hormone Actions.- Hormonal Actions Propagated by Release of Membrane Adenyl Cyclase.- Hormonal Actions Propagated by Participation of Cytosol and Nuclear Receptors.- 2. Hypothalamic-Pituitary-Ovarian Axis.- Maturation of Pituitary Gonadotropin Function in Females.- Ovarian Response to Gonadotropins.- Factors Affecting Ambient Levels of Gonadal Hormones.- Hypothalamic-Pituitary Control of Other Endocrine Functions.- 3. The Anterior Pituitary Gland.- Control of the Anterior Pituitary Gland.- Hormones Produced by the Anterior Pituitary Gland.- Assessment of Functions of the Anterior Pituitary Gland.- 4. Gonadal Development.- Ovary from Birth to Puberty.- Disorders of Sexual Development.- The Menstrual Cycle.- Corpus Luteum of Pregnancy.- Steroidogenesis in the Fetoplacental Unit.- Control of Steroidogenesis in Fetal Life.- Other Endocrine Changes in Pregnancy.- Endocrine Changes in the Maternal System in Pregnancy.- Endocrine Changes in Parturition.- Gestational Trophoblastic Neoplastic Syndromes.- 5. Pubertal Development and Disturbances of Menarche.- Changes in the Hypothalamic-Pituitary-Ovarian-Endometrium Axis at the Time of Puberty.- Disorders of Menarche.- 6. Amenorrhea.- Primary Amenorrhea.- Secondary Amenorrhea.- Procedures in Diagnosis of Amenorrhea.- Management of Amenorrhea.- Management of Hirsutism.- 7. Infertility.- Male Infertility.- Female Infertility.- Hormonal Methods of Contraception.- 8. The Breasts.- Maturation of Ductal and Lobule-Alveolar System.- Cyclic Changes in the Breast.- Breast Changes during Pregnancy.- Syndromes of Inappropriate Lactation (Galactorrhea).- Hormonal Effects on Breast Cancer.- 9. The Thyroid Gland.- Biosynthesis of Thyroid Hormones.- Transport of Thyroid Hormones.- Metabolism of Thyroid Hormones.- Regulation of Thyroid Activity.- Metabolic Effects of Thyroid Hormones.- Assessment of Thyroid Function.- Long-Acting Thyroid Stimulator.- Hyperthyroidism.- Hypothyroidism.- Thyroid Cancer.- 10. The Adrenal Cortex.- Adrenocortical Secretion.- Biosynthesis of Adrenocortical Hormones.- Transport of Adrenocortical Hormones.- Further Considerations of Synthesis of Androgens by the Adrenal Cortex.- Steroid Hormone Production in Fetal Adrenals.- Biologic Actions of Adrenocortical Hormones.- Catabolism of Adrenocortical Secretions.- Clinical Disorders of Adrenocortical Function.- Idiopathic Cyclic Edema.- Clinical Syndromes Due to Biosynthetic Defects in the Adrenal Cortex.- Idiopathic Hirsutism.- Feminizing Adrenocortical Tumors.- Laboratory Diagnosis of Adrenocortical Hyperplasia with Biosynthetic Defects.- Summary of Diagnostic Procedures.- 11. Special Topics.- Disorders of Carbohydrate Metabolism.- Clinical Application of Measurements of Hormones and Their Derivatives.
EAN: 9780852001363
ISBN: 0852001363
Untertitel: 1975. Auflage. Book. Sprache: Englisch.
Verlag: Springer
Erscheinungsdatum: August 1975
Seitenanzahl: 244 Seiten
Format: kartoniert
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