EBOOK

Interplay between Metal Ions and Nucleic Acids


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Januar 2012

Beschreibung

Beschreibung

Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics. The Metal Ions in Life Sciences series links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic and coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. MILS-10: Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics. The Editors Astrid Sigel, Helmut Sigel and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. They published on metal ion interactions with nucleotides and nucleic acids and on related topics, and edited previously 44 volumes in the series Metal Ions in Biological Systems.

Inhaltsverzeichnis

1. Characterization of Metal Ion-Nucleic Acid Interactions in Solution; Maria Pechlaner and Roland K. O. Sigel2. Nucleic Acid-Metal Ion Interactions in the Solid State; Katsuyuki Aoki and Kazutaka Murayama3. Metal Ion-Promoted Conformational Changes of Oligonucleotides; Bernhard Spingler4. G-Quadruplexes and Metal Ions; Nancy H. Campbell and Stephen Neidle5. Metal Ion-Mediated DNA-Protein Interactions; Barbara Zambelli, Francesco Musiani, and Stefano Ciurli6. Spectroscopic Investigations of Lanthanide Ion Binding to Nucleic Acids; Janet R. Morrow and Christopher M. Andolina7. Oxidative DNA Damage Mediated by Transition Metal Ions and Their Complexes; Geneviève Pratviel8. Metal Ion-Dependent DNAzymes and Their Applications as Biosensors; Tian Lan and Yi Lu9. Enantioselective Catalysis at the DNA Scaffold; Almudena García-Fernández and Gerard Roelfes10. Alternative DNA Base Pairing through Metal Coordination; Guido H. Clever and Mitsuhiko Shionoya11. Metal-Mediated Base Pairs in Nucleic Acids with Purine- and Pyrimidine-Derived Nucleosides; Dominik A. Megger, Nicole Megger, and Jens Müller12. Metal Complex Derivatives of Peptide Nucleic Acids; Roland Krämer and Andrij Mokhir

Pressestimmen

From the reviews: "Bioinorganic chemistry is an exciting branch of chemistry with applications in new materials (including sensors and tissues), health (diagnosis and therapy), energy supplies (generation and storage), biological function, evolution, and beyond. The Sigel volumes are always a reliable way of keeping abreast of this rapidly expanding field. This one is no exception. ... This book is a good read and all bioinorganic chemists might wish it was on their shelves-not only for research, but as a resource for undergraduate teaching" (Peter J. Sadler, Angewandte Chemie International Edition, Vol. 51, 2012) "'Interplay between Metal Ions and Nucleic Acids' ... is for the entire community of researchers interested in metal-nucleic acid interactions. Its contents are highly topical, as they cover numerous relevant areas of a research that faces rapid growth. Reading this volume is a 'must' for scientists active in this field, and the editors should be congratulated on the fine selection of chapters and authors. ... volume10 of MILS is among the very best books on this subject that have appeared in recent years!" (Bernhard Lippert, Inorganica Chimica Acta,Vol. 394, January, 2013) "This book will be an excellent companion to postgraduate students and established researchers interested in the essential role that metal ions play in the structure and function of nucleic acids. In addition, this volume will be of interest to scientists working towards the use of nucleic acids for sensing and catalytic applications, as well as for the development of novel nanomaterials." (Ramon Vilar, Transition Metal Chemistry, Vol. 37, 2012)
EAN: 9789400721715
ISBN: 9400721714
Untertitel: 'Metal Ions in Life Sciences'. 100 schwarz-weiße und 50 farbige Abbildungen, 20 schwarz-weiße Tabellen. Book. Sprache: Englisch.
Verlag: Springer-Verlag GmbH
Erscheinungsdatum: Januar 2012
Seitenanzahl: XXXIII
Format: gebunden
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