EBOOK

Modern Fluoroorganic Chemistry


€ 153,99
 
gebunden
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März 2013

Beschreibung

Beschreibung

The second edition of this classic reference work has been completely revised and updated, as well as being enlarged by 20% to reflect the latest developments in synthetic organic fluorine chemistry, taking into account new applications in materials science and medicinal chemistry.
The new developments in transition-metal-catalyzed methods for the introduction of fluorine and fluorinated groups are discussed. In addition, new chapters have been added on such important applications as organic electronics (OLEDs) and fluorinated dyes. Appendices containing synthetic procedures and conversions round off this comprehensive work.
This work is a valuable reference for fluorine chemists that also provides nonspecialists with an introduction to the field.
From reviews of the first edition:
''... a well-produced book with attractive graphics, photos and schemes. Throughout the book, coloured electrostatic maps of small
organofluorine compounds are used toillustrate charge distributions. These are effective as well as attractive. I would point any organic chemist to this book who wants to learn about and do some fluorine chemistry. It provides uncluttered descriptions and a clear orientation to the literature in this important area of the organic chemistry.''
CHEMBIOCHEM - A European Journal of Chemical Biology

Inhaltsverzeichnis

PREFACE TO THE SECOND EDITION
PREFACE TO THE FIRST EDITION
INTRODUCTION
Why Organofluorine Chemistry?
History
The Basic Materials
The Unique Properties of Organofluorine Compounds
PART I: Synthesis of Complex Organofluorine Compounds
INTRODUCTION OF FLUORINE
Perfluorination and Selective Direct Fluorination
Electrochemical Fluorination (ECF)
Nucleophilic Fluorination
Synthesis and Reactivity of Fluoroaromatic Compounds
Transformations of Functional Groups
''Electrophilic'' Fluorination
PERFLUOROALKYLATION
Radical Perfluoroalkylation
Nucleophilic Perfluoroalkylation
''Electrophilic'' Perfluoroalkylation
Difluorocarbene and Fluorinated Cyclopropanes
SELECTED FLUORINATED STRUCTURES AND REACTION TYPES
Difluoromethylation and Halodifluoromethylation
The Perfluoroalkoxy Group
The Perfluoroalkylthio Group and Sulfur-Based Super-Electron-Withdrawing Groups
The Pentafluorosulfanyl Group and Related Structures
THE CHEMISTRY OF HIGHLY FLUORINATED OLEFINS
Fluorinated Polymethines
Fluorinated Enol Ethers as Synthetic Building Blocks
PART II: Fluorous Chemistry
FLUOROUS CHEMISTRY
Fluorous Biphase Catalysis
FLUOROUS SYNTHESIS AND COMBINATORIAL CHEMISTRY
Fluorous Synthesis
Separation on Fluorous Stationary Phases
Fluorous Concepts in Combinatorial Chemistry
PART III: Applications of Organofluorine Compounds
HALOFLUOROCARBONS, HYDROFLUOROCARBONS, AND RELATED COMPOUNDS
Polymers and Lubricants
Applications in the Electronics Industry
Fluorinated Dyes
Liquid Crystals for Active Matrix Liquid Crystal Displays
Fluorine in Organic Electronics
PHARMACEUTICALS AND OTHER BIOMEDICAL APPLICATIONS
Why Fluorinated Pharmaceuticals?
Lipophilicity and Substituent Effects
Hydrogen Bonding and Electrostatic Interactions
Stereoelectronic Effects and Conformation
Metabolic Stabilization and Modulation of Reaction Centers
Bioisosteric Mimicking
Mechanism-Based ''Suicide'' Inhibition
Fluorinated Radiopharmaceuticals
Inhalation Anesthetics
Blood Substitutes and Respiratory Fluids
Contrast Media and Medical Diagnostics
Agricultural Chemistry
APPENDIX A: TYPICAL SYNTHETIC PROCEDURES
Selective Direct Fluorination
Hydrofluorination and Halofluorination
Electrophilic Fluorination with F-TEDA - BF4 (Selectfluor)
Fluorinations with DAST and BAST (Deoxofluor)
Fluorination of a Carboxylic Acid with Sulfur Tetrafluoride
Generation of a Trifluoromethoxy Group by Oxidative Fluorodesulfuration of a Xanthogenate
Oxidative Alkoxydifluorodesulfuration of Dithianylium Salts
Electrophilic Trifluoromethylation with Umemoto's Reagents
Nucleophilic Trifluoromethylation with Me3SiCF3
Transition Metal-Mediated Aromatic Perfluoroalkylation
Copper-Mediated Introduction of the Trifluoromethylthio Group
Substitution Reactions on Fluoroolefins and Fluoroarenes
Reactions with Difluoroenolates
APPENDIX B: INDEX OF SYNTHETIC CONVERSIONS
INDEX

Portrait

Peer Kirsch was born in Herford, Germany, in 1965. He received his PhD in 1993 from the University of Heidelberg. After a postdoctoral stay at the Institute of Physical and Chemical Research (RIKEN) in Saitama, Japan, he joined the Liquid Crystal Division of Merck KGaA, Darmstadt, in 1995, where he held various positions in R&D and Business Development in both Germany and Japan. After obtaining his postdoctoral lecturing qualification (habilitation) in 2001, he began teaching at the universities of Bremen and Freiburg. His scientific interests - besides fluorine chemistry - lie in the areas of liquid crystals and organic and molecular electronics.

Pressestimmen

"... a well-produced book with attractive graphics, photos and schemes. Throughout the book, coloured electrostatic maps of small organofluorine compounds are used to illustrate charge distributions. These are effective as well as attractive. I would point any organic chemist to this book who wants to learn about and do some fluorine chemistry. It provides uncluttered descriptions and a clear orientation to the literature in this important area of the organic chemistry." CHEMBIOCHEM - A European Journal of Chemical Biology
EAN: 9783527331666
ISBN: 3527331662
Untertitel: Synthesis, Reactivity, Applications. 2. vollständig überarbeitete und erweiterte Auflage. Revised, Enlarg. 34 schwarz-weiße und 18 farbige Abbildungen. Sprache: Englisch.
Verlag: Wiley VCH Verlag GmbH
Erscheinungsdatum: März 2013
Seitenanzahl: XX
Format: gebunden
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