Developmental Endocrinology

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Dezember 2012



Leading researchers comprehensively translate all the latest scientific information regarding endocrine physiology and development into an understanding of the clinical pathogenesis, diagnosis, and treatment of endocrine disease. Organized by endocrine system, each section of the book concisely describes the chronological development of the human organism, from the fetal/prenatal period through childhood, adolescence, and in some cases, into adulthood. The prenatal sections review recent discoveries concerning transcription factors, homeobox genes, and human molecular mutations-the basic processes governing prenatal development of the individual endocrine organs-and detail the pathophysiology, clinical characteristics, and treatment of pediatric endocrine disorders.


Part I. Hypothalamus/Pituitary

Transcriptional Control of the Development and Function of the Hypothalamic-Pituitary Axis
Gretchen E. Parker, Kyle W. Sloop, and Simon J. Rhodes

Part II. Growth

Molecular Mutations in the Human Growth Hormone Axis
Zvi Laron

Normal and Abnormal Growth
Emily C. Walvoord and Erica A. Eugster

Adult Growth Hormone Deficiency
Zehra Haider and James W. Edmondson

Part III. Thyroid

Molecular Mechanisms of Thyroid Gland Development: Insights from Clinical Studies and from Mutant Mice
Guy Van Vliet

Fetal-Perinatal Thyroid Physiology
Delbert A. Fisher

Thyroid Disorders in Children and Adolescents
Scott A. Rivkees

Part IV. Calcium and Bone

Genetic Control of Parathyroid Gland Development and Molecular Insights into Hypoparathyroidism
Michael A. Levine

Bone Physiology
Salvatore Minisola and Lorraine A. Fitzpatrick

Pediatric Bone Disease
Linda Anne DiMeglio

Part V. Gonadal Development

Transcriptional Development of the Hypothalamic-Pituitary-Gonadal Axis
Sally Radovick, Helen H. Kim, Diane E. J. Stafford, Andrew Wolfe, and Marjorie Zakaria

Sexual Differentiation
Tamara S. Hannon and John S. Fuqua

Prenatal Androgens and Sexual Differentiation of Behavior
Sheri A. Berenbaum

Normal and Precocious Puberty
Joan DiMartino-Nardi

Delayed Puberty
Steven G. Waguespack and Ora Hirsch Pescovitz

Part VI. Adrenal
Molecular Development of the Hypothalamic-Pituitary-Adrenal (HPA) Axis
Sophia P. Tsakiri, George P. Chrousos, and Andrew N. Margioris

Molecular Genetics of Adrenal Disease
Perrin C. White



"The coverage of calcium and bone is outstanding, being detailed, highly informative, wide-ranging - and dense! I was also highly impressed by the chapter on sexual differentiation, which is a model of clarity, well diagrammed and both informative and authoritative on clinical topics such as sex assignment. The chapter on precocious puberty is valuable for the clinician, as is the one on delayed puberty, which covers molecular and developmental aspects as well as clinical management. The final section of hypothalamic pituitary-adrenal development and genetic defects in steroidogenesis really is the icing on the cake, and completes what is a very impressive volume. the book is, above all, a valuable source of information for the reader, both scientist and clinician, who has specific questions to answer. Overall, is succeeds in fulfilling the editors' stated aims" -The Endocrinologist "The book presents an intensive evaluation of the genetic and molecular bases of developmental aspects of several endocrine systems, and the relationship of the new data to clinical medicine. The contributors are leaders in the field and each chapter is extensive and well documented. Developmental Endocrinology is packed with information, well referenced and well integrated with established concepts that form the physiological basis of endocrinology." - TRENDS in Endocrinology and Metabolism "Highly recommended to endocrinologists, neonatalogists and geneticists." -Eugster
EAN: 9781468496635
ISBN: 1468496638
Untertitel: From Research to Clinical Practice. Softcover reprint of the original 1st ed. 2002. Book. Sprache: Englisch.
Verlag: Humana Press
Erscheinungsdatum: Dezember 2012
Seitenanzahl: 432 Seiten
Format: kartoniert
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