Biomimetics and Stem Cells

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Juli 2014



Biomimetics and Stem Cells: Methods and Protocols collects a series of approaches to demonstrate the role and value of biomimetics for the better understanding of stem cell behavior and the acceleration of their application in regenerative medicine. Recent advances in tissue engineering are enabling scientists to ''instruct'' stem cells toward differentiating into the right phenotypes, in the right place and at the right time. Given these advances, biomimetic environments are being designed to recapitulate, in vitro, the combinations of factors known to guide tissue development and regeneration in vivo and thereby help unlock the full potential of the stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and essential, Biomimetics and Stem Cells: Methods and Protocols focuses on the use of biomimetic systems for stem cells in order to aid in moving this vital field of study forward.


1. Derivation and Network Formation of Vascular Cells from Human Pluripotent Stem Cells
            Sravanti Kusuma, Bria Macklin, and Sharon Gerecht
2. High-Throughput Cell Aggregate Culture for Stem Cell Chondrogenesis
            Ahmad E. Abu-Hakmeh and Leo Q. Wan
3. Microfluidic Device to Culture 3D In Vitro Human Capillary Networks
            Monica L. Moya, Luis F. Alonzo, and Steven C. George
4. Multi-Function Co-Culture Model for Evaluating Cell-Cell Interactions
            Danielle R. Bogdanowicz and Helen H. Lu
5. Multiwell Plate Tools for Controlling Cellular Alignment with Grooved Topography
            Camila Londono, John Soleas, Petra B Lücker, Suthamathy Sathananthan, J. Stewart Aitchison, and Alison P. McGuigan
6. Bioreactor Cultivation of Anatomically-Shaped Human Bone Grafts
            Joshua P. Temple, Keith Yeager, Sarindr Bhumiratana, Gordana Vunjak-Novakovic, and Warren L. Grayson
7. Determining the Role of Matrix Compliance in the Differentiation of Mammary Stem Cells
            KangAe Lee and Celeste M. Nelson
8. Conjugation of Proteins to Polymer Chains to Create Multivalent Molecules
            Anthony Conway, Dawn P. Spelke, and David V. Schaffer
9. An Assay to Quantify Chemotactic Properties of Degradation Products from Extracellular Matrix
            Brian M. Sicari, Li Zhang, Ricardo Londono, and Stephen F. Badylak
10. Biomimetic Strategies Incorporating Enzymes into CaP Coatings Mimicking the In Vivo Environment
            Ana M. Martins and Rui L. Reis
11. Fabrication of Biofunctionalized, Cell-Laden Macroporous 3D PEG Hydrogels as Bone Marrow Analogs for the Cultivation of Human Hematopoietic Stem and Progenitor Cells
            Lisa Rödling, Annamarija Raic, and Cornelia Lee-Thedieck
12. Extracellular Matrix Mimetic Peptide Scaffolds for Neural Stem Cell Culture and Differentiation
            Busra Mammadov, Mustafa O. Guler, and Ayse B. Tekinay
13. The Delivery and Evaluation of RNAi Therapeutics for Heterotopic Ossification Pathologies
            Arun R. Shrivats and Jeffrey O. Hollinger
14. Mimicking Bone Microenvironment for Directing Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation
            ZuFu Lu, Seyed-Iman Roohani-Esfahani, and Hala Zreiqat
15. Cultivation of Human Bone-Like Tissue from Pluripotent Stem Cell-Derived Osteogenic Progenitors in Perfusion Bioreactors
Giuseppe Maria de Peppo, Gordana Vunjak-Novakovic, and Darja Marolt


EAN: 9781493913312
ISBN: 149391331X
Untertitel: Methods and Protocols. 2014. Auflage. Book. Sprache: Englisch.
Verlag: Humana Press
Erscheinungsdatum: Juli 2014
Seitenanzahl: 200 Seiten
Format: gebunden
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