The Biology of the Laboratory Rabbit

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Oktober 2013



The Biology of the Laboratory Rabbit is a compendium of papers that discusses the use of the rabbit as an experimental substrate in the scientific process. The collection describes normative biology, research utilization, and rabbit disease. These papers emphasize naturally occurring diseases which affect the value of the rabbit as a research tool. Some papers describe these effects and their impact for investigators engaged in laboratory experimental work on animal medicine. Other papers tackle the value of certain rabbit diseases as models of considerable interest in comparative medicine. Several papers discuss bacterial diseases, viral diseases, protozoal diseases, arthropod parasites, helminth parasites, neoplastic diseases, inherited diseases, nutritional diseases, metabolic, traumatic, mycotic, and miscellaneous diseases of the rabbit. One paper describes a number of diseases that man can acquire from domestic and laboratory rabbits. These include tularemia (which is endemic in wild rabbits and hares), plague (transmitted by fleas), listeriosis (rare in laboratory rabbit colonies), salmonellosis (from rabbit feces), and Pasteurella multocida (common in laboratory and domestic rabbits). The paper notes that laboratory and domestic rabbits are not a major health hazard. The compendium can benefit veterinarians, the medically-oriented investigator, the biologist, the medical and chemical researcher, and others whose work involve laboratory animal care.


1;Front Cover;1 2;The Biology of the Laboratory Rabbit;6 3;Copyright Page;7 4;Table of Contents;8 5;List of Contributors;12 6;Preface;14 7;Chapter 1. Taxonomy and Genetics ;18 7.1;I. Taxonomy and Geographical Distribution of Rabbit Populations;18 7.2;II. Origin and Domestication of the Rabbit;19 7.3;lll. Genetics of the Rabbit;23 7.4;IV. Inbred Strains;34 7.5;References;34 8;Chapter 2. Colony Husbandry ;40 8.1;I. Introduction;40 8.2;II. Sexual Behavior and Breeding;41 8.3;III. Feeds and Feeding Behavior;47 8.4;IV. Commercial Herd Management;51 8.5;V. Laboratory Management;60 8.6;References;62 9;Chapter 3. The Anatomy, Physiology, and Biochemistry of the Rabbit ;66 9.1;I. Introduction;67 9.2;II. AnatomyNew Zealand White Rabbit;67 9.3;III. Physiology;73 9.4;IV. Biochemistry;77 9.5;V. Hematology;81 9.6;References;86 10;Chapter 4. Basic Biomethodology ;90 10.1;I. Introduction;91 10.2;II. Handling and Restraint;91 10.3;III. Sampling Techniques;91 10.4;IV. Methods of Compound Administration;93 10.5;V. Anesthesiology;94 10.6;VI. Specialized Research Techniques;100 10.7;VII. Euthanasia;104 10.8;VIII. Necropsy Procedures;104 10.9;References;106 11;Chapter 5. The Fetus in Experimental Teratology ;108 11.1;l. Introduction;109 11.2;II. Summarized Cyclic and Embryological Phenomena;110 11.3;III. Summarized Laboratory Techniques for Observation and Evaluation;114 11.4;IV. Fetal Pathology and Anatomical Variation;118 11.5;V. Teratological Investigation;147 11.6;VI. Conclusions;161 11.7;References;161 12;Chapter 6. Specialized Research Applications: I. ARTERIOSCLEROSIS RESEARCH ;172 12.1;I. Introduction and Scope of the Review;172 12.2;II.History of the Use of Rabbits in Arteriosclerosis Research;173 12.3;III.Naturally Occurring Arteriosclerosis of Rabbits;173 12.4;IV.Diet-Induced Atherosclerosis of Rabbits;173 12.5;V.Regression of Cholesterol-Induced Atherosclerosis of Rabbits;181 12.6;References;181 13;Chapter 7. Specialized Research Applications: II. Serological Genetics ;184 13
.1;I. The Blood Group Antigens;184 13.2;II. The Transplantation Antigens;190 13.3;References;193 14;Chapter 8. Gnotobiology ;196 14.1;I. Introduction;196 14.2;II. The Caesarian Concept;198 14.3;III. Hand Rearing;201 14.4;IV. Intestinal Flora;205 14.5;V. Sterility Testing;206 14.6;VI. Gnotobiotic Isolators and Their Maintenance;206 14.7;VII. Microbiological Monitoring and Histological Evaluation;207 14.8;VIII. Research Utilization;207 14.9;References;208 15;Chapter 9. Bacterial Diseases ;210 15.1;I. Introduction;211 15.2;II. Pasteurellosis;211 15.3;III. Tularemia;222 15.4;IV. Yersiniosis (Pseudotuberculosis);225 15.5;V. Necrobacillosis;227 15.6;VI. Salmonellosis;229 15.7;VII. Tyzzer's Disease;231 15.8;VIII. Listeriosis;236 15.9;IX. Tuberculosis;238 15.10;X. Treponematosis;241 15.11;XI. Staphylococcosis;244 15.12;XII. Miscellaneous Bacterial Diseases;245 15.13;References;248 16;Chapter 10. Viral Diseases ;254 16.1;I. Introduction;254 16.2;II. DNA Virus Infections;255 16.3;III. Diseases Caused by RNA Viruses;272 16.4;IV. Diseases Possibly of Viral Origin;274 16.5;References;274 17;Chapter 11. Protozoal Diseases ;280 17.1;I. General Introduction;280 17.2;II. Sporozoa;281 17.3;III. Toxoplasmida;287 17.4;IV. Microsporida;290 17.5;V. Flagellates and Amoebae;295 17.6;VI. Organisms of Uncertain Classification;297 17.7;References;299 18;Chapter 12. Arthropod Parasites ;304 18.1;I. Introduction;304 18.2;II. The Principal Arthropod Groups;305 18.3;References;327 19;Chapter 13. Helminth Parasites ;334 19.1;I. Introduction;334 19.2;II. Natural Infections;334 19.3;III. Experimental Infections;341 19.4;IV. Conclusions;343 19.5;References;343 20;Chapter 14. Neoplastic Diseases ;348 20.1;I. Introduction;349 20.2;II. Neoplasms of Oryctolagus sp.;353 20.3;III. Neoplasms of Sylvilagus sp.;372 20.4;IV. Neoplasms of Lepus sp.;373 20.5;V. Neoplasms Associated with Oncogenic Viruses;373 20.6;VI. Transplantable Neoplasms Used as Model Systems;383 20.7;References;386 21;Chapter 15. Inherited
Diseases and Variations;394 21.1;I. Introduction;394 21.2;II. Conditions Controlled by Single (Mutant) Genes;395 21.3;III. Familial or Polygenic Conditions;409 21.4;IV.Sources of Rabbits with Inherited Diseases and Variations;414 21.5;References;414 22;Chapter 16. Nutrition and Nutritional Diseases of the Rabbit ;420 22.1;I. Comparative Nutrition;420 22.2;II. Vitamins;423 22.3;III. Minerals;437 22.4;IV. Summary;445 22.5;References;445 23;Chapter 17. Metabolic, Traumatic, Mycotic, and Miscellaneous Diseases of Rabbits ;452 23.1;I. Introduction;452 23.2;II. Pregnancy Toxemia;453 23.3;III. Shock Disease;453 23.4;IV. Pylorospasm;454 23.5;V. Mucoid Enteropathy;454 23.6;VI. Superficial Mycoses;457 23.7;VII. Deep Mycoses;460 23.8;VIII. Mastitis;461 23.9;IX. Ulcerative Pododermatitis (Sore Hocks);461 23.10;X. Traumatic Vertebral Fracture (Traumatic Vertebral Dislocation, Paralysis of the Hindquarters, Broken Back);462 23.11;XI. Moist Dermatitis;462 23.12;XII. Heat Prostration;463 23.13;XIII. Hair Balls;463 23.14;XIV. Plant Toxicosis;464 23.15;XV. Band Keratopathy;465 23.16;XVI. Pulmonary Emphysema;465 23.17;XVII. Extrauterine Pregnancy (Abdominal Pregnancy, Ectopie Pregnancy);465 23.18;References;466 24;Chapter 18. Diseases of Public Health Significance ;470 24.1;I. Introduction;471 24.2;II. Bacterial Diseases;471 24.3;III. Mycotic Diseases;473 24.4;IV. Viral Diseases;473 24.5;V. Rickettsial Diseases;474 24.6;VI. Protozoan Diseases;474 24.7;VII. Helminth Diseases;475 24.8;VIII. Arthropod Infestations;475 24.9;References;475 25;Author Index;480 26;Subject Index;504


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EAN: 9781483270319
Untertitel: 200:Adobe eBook. Sprache: Englisch. Dateigröße in MByte: 104.
Verlag: Elsevier Science
Erscheinungsdatum: Oktober 2013
Seitenanzahl: 510 Seiten
Format: pdf eBook
Kopierschutz: Adobe DRM
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