The Impact of Food Bioactives on Health

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Mai 2015



"Infogest" (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the 'food and health' arena.


0.2 Introduction Paul Cotter and Kitty Verhoeckx 1.0 Gastrointestinal digestion models, general introduction Alan Mackie 1.1.0 Static digestion models general introduction Antonio Cilla 1.1.1 InfoGest consensus method Alan Mackie 1.1.2 Approaches to static digestion models Alan Mackie 1.2.0 Dynamic digestion models general introduction Eva Theunemann 1.2.1 The TNO gastro-Intestinal Model (TIM) Mans Minekus 1.2.2 Dynamic Gastric Model (DGM) Eva Thuenemann 1.2.3 Human Gastric Simulator (Riddet model) Paul Singh 1.2.4 The DIDGI® System Didier Dupont 2.0 General introduction to cells, cell lines and cell culture Tor Lea 2.1.0 Epithelial cell models; General introduction Tor Lea / Charlotte Kleiveland 2.1.1 Caco-2 cell line Tor Lea 2.1.2 HT29 cell line Isidra Recio 2.1.3 The IPEC-J2 cell line Hans Vergauwen (Gent) 2.1.4 Co-cultivation of Caco-2 and HT-29MT Charlotte Kleiveland 2.2 Innate and adaptive immune cells; General introduction Iván López Expósito 2.2.1 THP-1 and U937 cells Harry Wichers 2.2.2 Peripheral blood mononuclear cells Charlotte Kleiveland 2.2.3 PBMC-derived T cells Iván López Expósito 2.2.4 Dendritic Cells Maud Plantinga 2.2.5 Co-culture Caco-2/ immune cells Charlotte Kleiveland 2.3 Enteroendocrine Cell Models: General introduction Linda Giblin 2.3.1 STC-1 cells Linda Giblin (Teagasc) 2.3.2 NCI-H716 cells Jeffrey Gagnon & Patricia Brubaker 2.3.3 Murine GLUTag cells Patricia Brubaker 3.0 In vitro intestinal tissue models: General introduction Kitty Verhoeckx 3.1 Intestinal crypt organoids as experimental models Sabina Lukovac 3.2 Porcine ex vivo intestinal segment model Dina Ripken 3.3 Ussing chamber Joost Westerhout 4.0 In vitro fermentation models: General Introduction Dominika Swiatecka and Teresa Requena 4.1 One compartment fermentation model Anna-Marja Aura 4.2 The TNO in vitro model of the colon - TIM-2 Koen Venema 4.3 The Simulator of the Human Intestinal Microbial Ecosystem - SHIME® Tom van de Wiele 4.4 The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI Teresa Requena


EAN: 9783319157917
ISBN: 3319157914
Untertitel: In Vitro and Ex Vivo Models. 22 schwarz-weiße und 36 farbige Abbildungen, 30 schwarz-weiße Tabellen, Bibliographie. Book. Sprache: Englisch.
Verlag: Springer-Verlag GmbH
Erscheinungsdatum: Mai 2015
Seitenanzahl: xvii
Format: gebunden
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