COX-2 Inhibitors

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März 2004



COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.


List of contributors. Preface. R. M. Botting and J. H. Botting: The discovery of COX-2. Lawrence J. Marnett and Amit S. Kalgutkar: Structural diversity of selective COX-2 inhibitors. Guenter Trummlitz, Joanne van Ryn and Timothy D. Warner: The molecular and biological basis for COX-2 selectivity. Kim Rainsford: Pharmacology/ toxicology of COX-2 agents. Frank Degner: Efficacy and gastrointestinal safety of selective COX-2 inhibitors. Joanne van Ryn and Michel Pairet: Role of COX-2 in ulcers and ulcer healing. Rahul Nayak and Brendan F. McAdam: COX-2 and the cardiovascular system. Dirk O. Stichtenoth: Effects on the kidney: Role of COX-2 inhibitors. Koichi Hashimoto and R. Stokes Peebles Jr.: Effects on the lungs: Role of COX-2 inhibitors. Phillip R. Bennett and Aarthi R. Mohan: Reproduction: Role of COX-2 and its inhibition. Kirsi Saukkonen, Christianne J. Buskens, Anna Sivula, Bastiaan P. van Rees, Tiina-Liisa Erkinheimo, Johanna Rintahaka, Leena Pohjola, J. Jan B. van Lanschot, G. Johan A. Offerhaus, Caj Haglund and Ari Ristimäki: COX-2 in cancer. Index


EAN: 9783764369019
ISBN: 3764369019
Untertitel: Milestones in Drug Therapy. 'Milestones in Drug Therapy'. 2004. Auflage. Bibliographie. Book.
Verlag: Springer Basel AG
Erscheinungsdatum: März 2004
Seitenanzahl: X
Format: gebunden
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