New Therapeutic Targets in Rheumatoid Arthritis

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März 2009



This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter explores the biological rationale of a distinct therapeutic target in great detail. Readers will discover the latest in vitro work, animal models, and results from clinical trials.


B cell targets in rheumatoid arthritis.- Co-stimulatory pathways in the therapy of rheumatoid arthritis.- Immunobiology of IL-6 - Tocilizumab (Humanized anti-IL-6 receptor antibody ) for the treatment of RA.- Role of IL-1 in erosive arthritis, lessons from animal models.- Interleukin-15.- IL-17 and Th17 cells, key players in arthritis.- Role of il-18 in inflammatory diseases.- Chemokines and chemokine receptors.- Signaling pathways in rheumatoid arthritis.- Targeting oncostatin M in the treatment of rheumatoid arthritis.- Targeting the epigenetic modifications of synovial cells.- Perspectives in targeted therapy.
EAN: 9783764382377
ISBN: 3764382376
Untertitel: 'Progress in Inflammation Research'. Auflage 2009. Sprache: Englisch.
Verlag: Springer Basel AG
Erscheinungsdatum: März 2009
Seitenanzahl: XII
Format: gebunden
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