Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease

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November 2005



This exciting new book addresses the latest research on mast cells and basophils and its significance in relation to allergic and autoimmune diseases. This is an area of burgeoning interest, driven by increasing recognition of the fundamental importance of these cell types in several disease processes. The book covers recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils. It describes new technologies used to study these cells. It also discusses how the basic scientific findings can be integrated into possible therapeutic applications. The topics covered include (1) the development of mast cells and basophils; (2) early and late events in IgE/antigen activation of mast cells and basophils; (3) mechanisms of exocytosis; (4) non-IgE-mediated activation of mast cells and basophils, as well as of surface receptors that dampen activation responses; (5) protease, proteoglycan, lipid and cytokine mediators released from activated mast cells and basophils; and (6) bilateral interactions of mast cells with other cell types. The book focuses on the role of mast cells and basophils in disease. Some of the discussions examine the part played by mast cells in allergic inflammation and the effect of stabilization of these cells in novel therapies. There is also discussion of mastocytosis and the underlying mutations. Recent evidence implicates mast cells in multiple sclerosis, diabetes and HIV-1 infection, and other studies identify mast cells in processes that control the onset and severity of experimental allergic encephalomyelitis and insulin-dependent diabetes in mice. The strategic location of mast cells in the central nervous system (in multiple sclerosis) and in the pancreas (in diabetes), as well as their ability to express a variety of cytokines and other inflammatory mediators, raises the possibility that mast cells either initiate the inflammatory responses directly or modulate the character of the T cell response. Up-to-date and containing contributions from world leaders in the field, this book will be required reading for basic scientists and clinicians with an interest in mast cells and the related diseases.


Symposium on Mast cells and basophils: development, activation and roles in allergic/autoimmune disease, held at the Novartis Foundation, London, 16-18 November 2004
Editors: Derek J. Chadwick (Organizer) and Jamie Goode
This symposium was based on a proposal made by Santa Jeremy Ono.
Santa Jeremy Ono: Chair's Introduction.
Yukihiko Kitamura MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells
Paul J. Bryce, Mendy L. Miller, Ichiro Miyajima, Mindy Tsai, Stephen J. Galli and Hans C. Oettgen: Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells
Yasuko Furumoto, Gregorio Gomez, Claudia Gonzalez-Espinosa, Martina Kovarova, Sandra Odom, John J. Ryan and Juan Rivera: The role of Src family kinases in mast cell effector function
Richard L. Stevens, Nasa Morokawa, Jing Wang and Steven A. Krilis: RasGRP4 in mast-cell signalling and disease susceptibility
J. Abramson, E. A. Barbu and I. Pecht: Regulation of mast cell secretory response to the type I Fce receptor: inhibitory elements and desensitization
General discussion I.
Toshiaki Kawakami, Jiro Kitaura, Wenbin Xiao and Yuko Kawakami: IgE regulation of mast cell survival and function
See-Ying Tam, Janet Kalesnikoff, Susumu Nakae, Mindy Tsai and Stephen J. Galli: RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
Masako Toda, Takao Nakamura, Masaharu Ohbayashi, Yoshifumi Ikeda, Maria Dawson, Ricardo Micheler Richardson, Andrew Alban, Benjamin Leed, Dai Miyazaki and Santa Jeremy Ono: Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FceRI- and/or CCR1-engaged mast cells using protein chip technology
General discussion II.
Shigeo Koyasu, Akiko Minowa, Yasuo Terauchi, Takashi Kadowaki and Satoshi Matsuda: The role of phosphoinositide-3-kinase in mast cell homing to the gastrointestinal tract
K. Frank Austen: The mast cell and the cysteinyl leukotrienes
Silvia Monticelli, K. Mark Ansel, Dong U. Lee and Anjana Rao: Regulation of gene expression in mast cells: micro-RNA expression and chromatin structural analysis of cytokine genes
Cellina Cohen-Saidon and Ehud Razin: The involvement of Bcl-2 in mast cell apoptosis
General discussion III.
P. A. Nigrovic and D. M. Lee: Mast cells in autoantibody responses and arthritis
Greg D. Gregory, Allison Bickford, Michaela Robbie-Ryan, Mindy Tanzola and Melissa A. Brown: MASTering the immune response: mast cells in autoimmunity
Dean D. Metcalfe: Mastocytosis
Index of Contributors.
Subject Index.


"This is an excellent resource for clinicians or basic scientists with an interest in mast cells and related diseases." (Doody's Health Services)
EAN: 9780470013120
ISBN: 0470013125
Untertitel: 'Novartis Foundation Symposium'. Sprache: Englisch.
Erscheinungsdatum: November 2005
Seitenanzahl: 259 Seiten
Format: gebunden
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