EBOOK

Drug Delivery Systems in Cancer Therapy


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September 2003

Beschreibung

Beschreibung

A major difficulty in successfully treating cancer with drugs is achieving adequate drug concentrations in the diseased areas without overexposing drug-sensitive normal tissues. In a number of cases, specialized drug delivery systems are required to realize a therapeutic gain. In Drug Delivery Systems in Cancer Therapy, Dennis M. Brown has assembled a panel of leading experts to survey all the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. They also profile the use of novel formulation technologies-including synthetic polymers and biomaterials for sustained drug release to achieve greater therapeutic effect-that have demonstrated efficacy in a number of approved and late-stage clinical products. They also consider the benefits of, and future opportunities for, various drug delivery systems, as well as the experimental techniques used in their evaluation. Although the focus is primarily on small molecule delivery, many of the technologies described can also be effective in delivering larger biomolecules. Comprehensive, cutting-edge, and highly practical, Drug Delivery Systems in Cancer Therapy captures for experimental oncologists, medicinal chemists, and pharmacologists the universe of approaches, technologies, and systems available for substantially enhancing the therapeutic outcome of anticancer drug delivery today. Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Inhaltsverzeichnis

Part I: Pharmacological Considerations for Drug Delivery Systems in Cancer Medicine

Systemically Administered Drugs
Reginald B. Ewesuedo and Mark J. Ratain

Regional Administration of Antineoplastic Drugs
Maurie Markman

Theoretical Analyses and Simulations of Anticancer Drug Delivery
Ardith W. El-Kareh and Timothy W. Secomb

Part II: Technologies Available for Use in Cancer Drug Delivery Systems

Biopolymers for Parenteral Drug Delivery in Cancer Treatment
Wolfgang Friess

Hydrogels in Cancer Drug Delivery Systems
Sung-Joo Hwang, Namjin Baek, Haesun Park, and Kinam Park

Microparticle Drug Delivery Systems
Duane T. Birnbaum and Lisa Brannon-Peppas

Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Future
Robert G. L. Shorr, Michael Bentley, Simon Zhsao, Richard Parker, and Brendan Whittle

Emulsions As Anticancer Delivery Systems
S. Esmail Tabibi

Part III. Current Applications: Products Approved or in Advanced Clinical Development

Liposomal Drug Delivery Systems for Cancer Therapy
Daryl C. Drummond, Dmitri Kirpotin, Christopher C. Benz, John W. Park, and Keelung Hong

Gliadel®: A New Method for the Treatment of Malignant Brain Tumors
Francesco DiMeco, Henry Brem, Jon D. Weingart, and Alessandro Olivi

Intralesional Chemotherapy with Injectable Collagen Gel Formulations
Elaine K. Orenberg

Sustained-Release Drug Delivery with DepoFoam
Sankaram B. Mantripragada and Stephen B. Howell

Cancer Vaccines
Susanne Osanto

Part IV. Future Directions: Novel Cancer Drug Targets and Delivery Systems

Gene Therapy of Cancer
Susanne Osanto

Progress in Antisense Technology
Stanley T. Crooke

Tumor Vaccines
Francesco M. Marincola

Diagnosis and Treatment of HumanDisease Using Telomerase As a Novel Target
Lynne W. Elmore and Shawn E. Holt

Index

Pressestimmen

"this book should serve as a valuable resource to anyone interested in the field of drug delivery systems in cancer therapy. It would be particularly useful to individuals developing novel agents that might benefit from selective packaging and delivery approaches."-Doody's Health Sciences Book Review Journal
"The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development." - Tumori
"...provide(s) concise and easily understandable clinical significance, current status, and future perspective of anticancer drug delivery." - Pharmaceutical Research
EAN: 9780896038882
ISBN: 0896038882
Untertitel: 2004. Auflage. Sprache: Englisch.
Verlag: SPRINGER VERLAG GMBH
Erscheinungsdatum: September 2003
Seitenanzahl: 390 Seiten
Format: gebunden
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