Immunotherapy for Infectious Diseases

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April 2002



Because the search for safe and effective chemotherapeutic agents has been hindered by antimicrobial resistance and toxic harm, there is a growing need to understand how the immune system can be manipulated to control infections, particularly HIV. In Immunotherapy for Infectious Diseases, Jeffrey M. Jacobson, md, and a group of leading researchers active in the field review the state-of-the-art for treating various infections-particularly HIV-by manipulating the immune system's response rather than by using chemical drugs. The contributors synthesize the principles of immune defense on the molecular level (monoclonal antibodies, vaccines, methods of antigen presentation, and cytokines and cytokine antagonists), as well as on the cellular and clinical levels as a protection against infection. The review of the current state of anti-HIV immunotherapy covers HIV-specific passive and active immunization strategies, gene therapy, and host cell-targeted approaches for treating HIV infection and restoring immune function. Also discussed are immunotherapy for other viral infections, virus-associated malignancies, bacterial infections and sepsis, tuberculosis, and fungal infections. Comprehensive and cutting-edge, Immunotherapy for Infectious Diseases reviews all the current state-of-the-art developments occurring in this rapidly evolving field and helps set the stage for the early development of better immunologically based therapies for infections.


Part I. Basic Principles of Immunity

Humoral Immunity
Peter L. Nara

Some Basic Cellular Immunology Principles Applied to the Pathogenesis of Infectious Diseases
R. Pat Bucy and Paul Goepfert

Immune Defense at Mucosal Surfaces
Prosper N. Boyaka and Jerry R. McGhee

Part II. Molecular Basis for Immunotherapy

Production of Immunoglobulins and Monoclonal Antibodies Targeting Infectious Diseases
Renate Kunert and Hermann Katinger
Dendritic Cells: Their Role in the Immune Response to Infectious Organisms and Their Potential Use in Therapeutic Vaccination
Smriti K. Kundu-Raychaudhuri and Edgar G. Engleman

Cytokines, Cytokine Antagonists, and Growth Factors for Treating Infections
Barbara G. Matthews

Principles of Vaccine Development
Constantin A. Bona

Part III. Immunotherapy for HIV Infection

Immunopathogenesis of HIV Infection
Lawrence M. Fox.

Immune Reconstitution with Antiretroviral Chemotherapy
Elizabeth Connick

Active Immunization as Therapy for HIV Infection
Spyros A. Kalams

Passive Immunotherapy for HIV Infection
Jeffrey M. Jacobson

Host Cell-Directed Approaches for Treating HIV and Restoring Immune Function
J. Michael Kilby and R. Pat Bucy

Gene Therapy for HIV-1 Infection
Ralph Dornburg and Roger J. Pomerantz

Part IV. Immunotherapy for Infectious Diseases Other than HIV

Immunotherapy for Viral Infections Other than HIV
Michelle Onorato and Richard B. Pollard

Immunotherapy for Virus-Associated Malignancies
Uluhan Sili, Helen Heslop, and Cliona M. Rooney

Immunotherapy of Bacterial Infections and Sepsis
Sam T. Donta

Immunotherapy for Tuberculosis and Other Mycobacterial Infections
Robert S. Wallis and John L. Johnson

Immunotherapy for Fungal Infections



"This book is extemely well-organiaed, and while it conains alot of new information, it is easy to read due to its presentation. Thus, while each chapter could stand alone, the way in which the information is integrated enhances its clarity as the format melds the old information with the new. Finally, the topic is timely and comprehensive." -Doody's Health Sciences Book Review Journal
EAN: 9780896036697
ISBN: 0896036693
Untertitel: 2002. Auflage. Sprache: Englisch.
Erscheinungsdatum: April 2002
Seitenanzahl: 344 Seiten
Format: gebunden
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