Modern Therapeutics in Rheumatic Diseases

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November 2001



Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.


I. Rheumatoid Arthritis
Larry W. Moreland, Section Editor

New Treatment Opportunities for Rheumatoid Arthritis
Larry W. Moreland

Genetic Influences on Treatment Response in Rheumatoid Arthritis
S. Louis Bridges, Jr. and Robert P. Kimberly

Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis
John S. Sundy

Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs
M. Elaine Husni and Lee S. Simon

Glucocorticoid Therapy in Rheumatoid Arthritis
Kenneth G. Saag and John R. Kirwan

Anti-Tumor Necrosis Factor Agents
Alan K. Matsumoto and Joan M. Bathon

Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis
Barry Bresnihan

Leflunomide: An Immunomodulatory Drug for the Treatment of Rheumatoid Arthritis
Paul Emery, David L. Scott, and Vibeke Strand

Matrix Metalloproteinase Inhibitors as Therapies for Rheumatoid Arthritis
Sean J. Wollaston and Kenneth C. Kalunian

Combination Disease-Modifying Anti-Rheumatic Drug (DMARD) Therapy
James R. O'Dell

Experimental Therapeutics for Rheumatoid Arthritis
Mark C. Genovese and William H. Robinson

II. Osteoarthritis
Jean-Pierre Pelletier and Johanne Martel-Pelletier, Section Editors

Slow-Acting Drugs for the Treatment of Osteoarthritis
Jean-Yves Reginster and Roy D. Altman

Intra-Articular Therapy in Ostheoarthritis
Boulos Haraoui and Jean-Pierre Raynauld

Promoting Articular Cartilage Repair
Joseph A. Buckwalter and James A. Martin

Using Molecular Markers to Monitor Osteoarthritis
Ivan G. Otterness and Mary J. Saltarelli

New Therapeutic Targets for Osteoarthritis: The Rewards of Research
Jean-Pierre Pelletier, Johanne Martel-Pelletier, and Pamela Manning

Recent Developments in the Therapy of Osteoarthritis
Jean-Pierre Pelletier and Johanne Martel-Pelletier

III. Systemic Autoimmune Diseases
Gary M. Kammer and George C. Tsokos, Section Editors

Treatment of Systemic Lupus Erythematosus
Peter H. Schur and Gary M. Kammer

Treatment of the Antiphospholipid Syndrome
Joan T. Merrill

Treatment of Systemic Lupus Erythematosus by Blocking T-Cell Costimulation
David I. Daikh and David Wofsy

Current Management of Systemic Sclerosis
Clarence W. Legerton III and Richard M. Silver

Sjögren's Syndrome
Robert W. Hoffman and Eric L. Greidinger

Mixed Connective Tissue Disease
Robert W. Hoffman and Eric L. Greidinger

Dimitrios Vassilopoulos and Leonard H. Calabrese

Treatment of Juvenile Rheumatoid Arthritis
Laura J. Mirkinson and Ildy M. Katona

Treatment of Inflammatory Myopathies
William R. Gilliland

Psoriatic Arthritis
Dimitrios T. Boumpas and Gabor G. Illei

Complement Inhibitors in Rheumatic Diseases
Sherry D. Fleming and George C. Tsokos

Hematopoietic Stem Cell Transplantation of Autoimmune Disease
Richard K. Burt and Ann E. Traynor

IV. Gene Therapy in Rheumatic Diseases
Steffen Gay, Section Editor

Vectors for Gene Delivery
Sandro Rusconi and Maurizio Ceppi

Gene Targeting of Cytokines and the Mitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse Model
Jörg Schedel, Thomas Pap, Ulf Müller-Ladner, Renate E. Gray, and Steffen Gay

Retroviral Transduction of Antigen-Specific CD4+ T Cells for Local Delivery of Regulatory Molecules
Gina L. Costa and C. Garrison Fathman

Gene Transfer to Lymphocytes Targeting Cartilagineous Collagen Type II
Alexander E. Annenkov and Yuti Chernajovsky

Gene Therapy in Murine Arthritis:


"It is indeed most helpful to those practicing Rheumatology. The author is a credible authority in the subject matter of the book...This book covers an exhaustive list of therapeutic topics. From familiar- such as Non Steroidal Drugs to unusual such as Apoptosis Regulation have been discussed in detail. Subjects such as Gene Therapy are especially well covered. The unique aspect of this book has to be its ability to discuss the latest knowledge in depth without losing sight of its primary objective; examining its clinical applicability...this book will prove to be of incomparable value; especially to practicing rheumatologists. It lays forth clearly what can be offered to the patient and why it may be of benefit when faced with the bewildering choices of therapeutic options available today. There are really no other books quite like it." -Doody's Health Sciences Book Review Journal
"This book could not have been published at a better time from the rheumatology trainee's point of view. It is written in a coherent and concise manner, which serves as an excellent source for all aspects of therapeutics in the rheumatic diseases. Furthermore, the frequent use of diagrams and graphs allowed emphasis of key points. This publication links the basic science of rheumatic diseases to a comprehensive text of therapeutic mechanisms and efficacy." -The Journal of Rheumatology
EAN: 9780896039162
ISBN: 0896039161
Untertitel: 2002. Auflage. Sprache: Englisch.
Erscheinungsdatum: November 2001
Seitenanzahl: 656 Seiten
Format: gebunden
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