Complement and Kidney Disease

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Dezember 2005



The understanding how complement relates to glomerular diseases
has evolved considerably during the last years. Substantial
evidence has accumulated that explain how a defective or
deregulated complement system results in kidney diseases. The
combination and close interaction of basic research with clinical
medicine has demonstrated an important role of complement effector
and regulatory proteins in pathological settings of the kidney.

A large panel of distinct human kidney diseases such as hemolytic
uremic syndrome (HUS), membrano proliferative glomerulonephritis
(MPGN), systemic lupus erythematosus (SLE) and in ischemic
reperfusions injury and transplantation are caused by defective
complement control. Genetic analyses have identified mutations in
complement regulators that are associated with these diseases.
Mutations have been identified in the fluid phase alternative
pathway regulator Factor H and the membrane regulator Membrane
Cofactor Protein MCP (CD46). The functional characterization of the
mutant proteins allows to define the pathophysiological events on a
molecular level. These new concepts and data on disease mechanisms
already allowed to establish new diagnostic and novel promising
therapeutic approaches for several human kidney diseases.


The complement system in renal diseases.- Complement in renal transplantation.- C1q and the glomerulonephritides: therapeutic approaches for the treatment of complement-mediated kidney diseases.- Complement deficient mice as model systems for kidney diseases.- Non-Shiga toxin-associated hemolytic uremic syndrome.- Role of complement and Factor H in hemolytic uremic syndrome.- Genetic testing in atypical HUS and the role of membrane cofactor protein (MCP; CD46) and Factor I.- Towards a new classification of hemolytic uremic syndrome.- Therapeutic strategies for atypical and recurrent hemolytic uremic syndromes (HUS).- Complement defects in children which result in kidney diseases: diagnosis and therapy.- The role of complement in membranoproliferative glomerulonephritis.- The experience of a patient advocacy group.


EAN: 9783764371661
ISBN: 3764371668
Untertitel: 'Progress in Inflammation Research'. 2006. Auflage. Book. Sprache: Englisch.
Verlag: Birkhäuser
Erscheinungsdatum: Dezember 2005
Seitenanzahl: 260 Seiten
Format: gebunden
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