The Window of Opportunity: Pre-Pregnancy to 24 Months of Age

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Februar 2008



There is no longer any doubt that the inherited genetic constitution of the individual has a large influence on the entire life cycle, from human fetal development and pre- and postnatal growth to subsequent health status. However, growing evidence suggests that this predisposition is not rigid, but that early genetic imprinting, caused by exposure to a diverse spectrum of nutrients, macromolecules, microbial agents and other cellular or soluble components present in the external environment, is also of importance. According to this concept of the developmental origins of adult diseases, intrauterine and early life events play an important role in the etiology of human diseases: there seems to exist a critical 'window of opportunity' in the human infant before and during pregnancy, and up to 24 months of age. Altered exposure to different environmental agents during this critical period may determine the nature of responses in the perinatal period, and the expression of specific disease states in later life. The papers presented in this publication thus focus on the impact of perinatal growth, nutrition, environmental microflora, and host immune responses on the outcome of health and disease in later life.


Preface; Foreword; Contributors; Growth and Later Health; The Biology of Growth: Cameron, N.; Human Growth and Cardiovascular Disease: Barker, D.J.P.; The Role of Growth in Heart Development: Thornburg, K.L.; Louey, S.; Giraud, G.D.; Growth and Bone Development: Cooper, C.; Harvey, N.; Javaid, K.; Hanson, M.; Dennison, E.; The Role of Genes in Growth and Later Health: Eriksson, J.G.; Growth and Nutrition during Critical Windows; Maternal Nutrition Before and During Pregnancy: Scholl, T.O.; The Diabetic Pregnancy, Macrosomia, and Perinatal Nutritional Programming: Plagemann, A.; Harder, T.; Dudenhausen, J.W.; Undernutrition and Growth Restriction in Pregnancy: Bergmann, R.L.; Bergmann, K.E.; Dudenhausen, J.W.; Growth and Nutrition: The First Six Months: Hanson, L.A; Zaman, S.; Werner, B.; Haversen, L.; Motas, C.; Moisei, M.; Mattsby-Baltzer, I.; Lange, S.; Banasaz, M.; Midtvedt, T.; Norin, E.; Silverdal, S.-A.; Growth in the First Two Years of Life: Bier, D.M.; Growth and Immunity; Effects of Early Environment on Mucosal Immunologic Homeostasis, Subsequent Immune Responses and Disease Outcome: Ogra, P.L.; Welliver, R.C. Sr.; Induction of Antigen-Specific Immunity in Human Neonates and Infants: Wilson, C.B.; Kollmann, T.R.; Growth and Host-Pathogen Interactions: Prentice, A.M.; Darboe, M.K.; Neonatal Microbial Flora and Disease Outcome: Vassallo, M.F.; Walker, W.A.; Impact of Fetal and Neonatal Viral (and Parasitic) Infections on Later Development and Disease Outcome: Maldonado, Y.A.; Environmental Influences on the Development of the Immune System: Consequences for Disease Outcome: Bjorksten, B.
EAN: 9783805583879
ISBN: 3805583877
Untertitel: 61st Nestlé Nutrition Workshop, Pediatric Program, Bali, April 2007. 'Nestlé Nutrition Institute Workshop Series'. Tables:28. Sprache: Englisch.
Verlag: Karger Verlag
Erscheinungsdatum: Februar 2008
Seitenanzahl: 266 Seiten
Format: gebunden
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