Overcoming Steroid Insensitivity in Respiratory Disease

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März 2008



Since their discovery in the 1950's, the therapeutic use of corticosteroids has been the mainstay of treatment for many chronic inflammatory diseases. Their utility has been tempered, however, by the increasing risk of side effects with higher dose therapy. In the treatment of airways diseases, side-effects can be limited by targeted delivery to the airway and lung, and significant progress has been made through the use of increasingly selective molecules, and through a variety of lung targeting strategies. Moreover, the recent developments in our understanding of the molecular and structural mechanisms of action of corticosteroid actions have suggested that it may be possible to develop new corticosteroids with intrinsically different pharmacology. A combination of these developments will enable the design of agents with an enhanced therapeutic index and this book, aimed at specialists in pulmonology, provides the clinician who prescribes corticosteroid therapies with the most up-to-date information on one of the most significant therapeutic challenges to effective management of chronic inflammatory diseases. * First book dedicated specifically to this major management issue for respiratory and general physicians. * Authors well-known experts in field. * Reviews important new advances in therapeutics.


List of contributors
1 Molecular Mechanisms of Glucocorticoid Receptor Action
Pankaj Bhavsar and Ian M. Adcock
2 Side Effects of Topical and Oral Glucocorticoids
Heike Schäcke, Khusru Asadullah and Wolf-Dietrich Döcke
3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity
Robert H. Oakley and John A. Cidlowski
4 Dissociated Glucocorticoids
Ian M. Adcock
5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms
Evangelia Charmandari, Tomoshige Kino and George P. Chrousos
6 Corticosteroid Responsiveness in Asthma: Clinical Aspects
Kian Fan Chung
7 Glucocorticoid-insensitive Asthma: Molecular Mechanisms
John W. Bloom
8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness
Irfan Rahman and David Adenuga
9 Regulation of Glucocorticoid Sensitivity by Macrophage Migration Inhibitory Factor
Eric F. Morand
10 Steroid-sparing Strategies: Long-acting Inhaled ²2 -Agonists
Anna Miller-Larsson and Olof Selroos
11 Steroid-sparing Strategies: Other Combinations
Gaetano Caramori, Kazuhiro Ito and Alberto Papi
12 Kinases as Anti-inflammatory Targets for Respiratory Disease
Iain Kilty
13 Pharmacokinetic/Pharmacodynamic Factors and Steroid Sensitivity
Gönther Hochhaus
14 Improved Lung Deposition: New Inhaler Devices
Omar S. Usmani
EAN: 9780470058084
ISBN: 0470058080
Untertitel: Illustrations. Sprache: Englisch.
Verlag: John Wiley and Sons Ltd
Erscheinungsdatum: März 2008
Seitenanzahl: 304 Seiten
Format: gebunden
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