Enzymatic Baeyer-Villiger Oxidation for Natural Product Synthesis

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Mai 2008



The introduction of enzymes as catalysts into synthetic organic chemistry opened access to many new and highly enantioselective transformations. Baeyer-Villiger oxidation using biocatalysts represents a powerful methodology for the one-step asymmetric synthesis of chiral lactones. Due to a large number of different Baeyer-Villiger monooxygenases (BVMOs) with so far unknown biocatalytic properties the development of an efficient screening methodology based on microscaled whole-cell biotransformations became mandatory. The fermentation optimization of whole-cell mediated Baeyer-Villiger oxidation was the next logical step. A two-in-one in situ substrate feeding and product removal concept (SFPR) using an adsorbent resin and a recombinant E.coli strain was elaborated. Several critical parameters of the fermentation process were optimized. This work spans from biocatalyst assignment within screening protocols to up-scaling of the process to, ultimately, applying this biotransformation in the synthesis of natural compounds. This book is a very valuable contribution to the scientific community especially for people which are interested in the field of applied biocatalysis.


Florian Rudroff; Dipl.-Ing. Dr. techn.: Graduated in Organic Chemistry at Vienna University of Technology in the field of Applied Biocatalysis in March 2007; Post Doctoral position in the research group of Prof. Marko Mihovilovic.
EAN: 9783639020939
ISBN: 3639020936
Untertitel: From Parallel Mini-Scale Screening to Fermenter Up-Scaling. Paperback. Sprache: Englisch.
Verlag: VDM Verlag
Erscheinungsdatum: Mai 2008
Seitenanzahl: 200 Seiten
Format: kartoniert
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